Informatics Publishing Limited

D. Sarojini ¹, P. Sunitha ², L. K. Kanthal ², K. Lavanya ², Kausik Bhar ²

Affiliations
1 Koringa College of pharmacy, Korangi, East Godavari Dist., - 533462, Andhra Pradesh, IN
2 Koringa College of Pharmacy, Korangi-533461, Tallarevu (M), East Godavari Dist., Andhra Pradesh, IN

Abstract

The present study focussed on the clinical profile of patients with acute severe pancreatitis on carbapenem Vs. non carbapenems. Out of 55 patients 22 patients were given carbapenem antibiotics and rest were given non carbapenem antibiotics which comprises of cephalosporins, fluoroquinolones, Piperacillin+tazobactum, Metronidazole. In the carbapenem group 20 patients were initially on cephalosporins and later they were started on carbapenem as they were not improving. In these 20 patients, renal failure is observed in 14 patients and respiratory failure in 6 patients. All these 20patients survived and they stayed in hospital for 3-5 weeks. Two patients in carbapenem group died and they had renal and respiratory failure even they were started on carbapenem in the first week. These two patients stayed in hospital for 3weeks. A total of 33 patients were given non carbapenem antibiotics. Out of 33 patients 16 patients had renal failure and 12 patients had multiorgan failure. 8 patients had local complications in form of multiple fluid collections and necrosis more than 50%. 22 out of patients received cefaperazone+sulbactum with Fluoroquinolones. 7 patients received only Piperacillin+Tazobactum with Fluoroquinolones. 4 patients received only Fluoroquinolones. 30patients who were on cephalosporins stayed 2-3 weeks and all 30 patients improved and were discharged. 3 Patients out of 33 died in the first week due to multiorgan failure. This study conclude that cefaperazone sulbactum along with quinolone is a good first choice antibiotic and reserve the imipenem for sicker and non responders to cephalosporins.

Keywords

Acute Severe Pancreatitis, Carbapenem Antibiotics, Non-Carbapenem, Respiratory Failure, Multiorgan Failure, Fluoroquinolones.

Full Text

     

Sumanta Mondal ¹, Kausik Bhar ², Naresh Panigrahi ¹, Prasenjit Mondal ³, Sridhar Nayak ¹, Rudra Pratap Barik ⁴, Koyyana Aravind ⁴

Affiliations
1 Department of Pharmaceutical Chemistry, Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam – 530045, Andhra Pradesh, IN
2 Department of Pharmaceutical Chemistry, Bengal School of Technology, Sugandha, Delhi Road, Hooghly – 712102, West Bengal, IN
3 Department of Pharmaceutical Chemistry, Vaageswari Institute of Pharmaceutical Sciences, Ramakrishna Colony, Karimnagar – 505481, Telangana, IN
4 Department of Pharmaceutical Chemistry, Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam – 530045, Andhra Pradesh, IN

Abstract

Spondias pinnata (L.f.) Kurz., belongs to the Anacardiaceae family, generally referred to as Indian Hog plum, a deciduous, glabrous tree with a healthy fruit to eat. Hog plum is a mild deciduous tree plant of high nutritional value, stubby calories and abundant in vegetable proteins, zinc, chitin, starch, vitamins and minerals. Traditional use of various parts of S. pinnata includes diarrhea, dysentery, stomach troubles, hyperacidity, wounds, sprain, rheumatism, gonorrhoea, tuberculosis, aphrodisiac, arrow poison antidote, dyspepsia, dysentery, ring worms, abscess painful joints, refrigerant, tonic, antiseptic, astringent, mental disorders, tuberculosis, vomiting and many more. A number of pharmacological activities were reported from several extracts of S. pinnata and its parts that include hypoglycemic, anti-cancer, ulcer-protective, antidiarrhoeal, anti-microbial, hepatoprotective, thrombolytic, anti-inflammatory, antiarthritic, analgesic, antipyretic, antihypertensive, anthelmintic, diuretic and laxative, anti-tuberculosis, cytotoxic, antioxidant, anti-hyperlipidemic, ischemia reperfusion injury and preconditioning of heart, anxiolytic, reduce side effects of chemotherapy, ameliorating, platelet aggregation inhibitory activity and acute and sub-chronic toxicity. A few phytochemicals were detailed on this plant. The chemical components of S. pinnata include different amino acids, carbohydrates, terpenoids, flavonoids, polysaccharides, steroids and so on. Various solvent extract and their gas chromatography-mass spectrometry analysis have confirmed the structures of a number of important phytoconstituents. Hence this review can be a good reference for researchers who would undertake further investigation about S. pinnata.

Keywords

Hog Plum, Pharmacological Activities, Phytoconstituents, Spondias pinnata, Traditional Use

Full Text